Cover Image




Plexiform neurofibroma is a benign tumor of  peripheral nerves arising from a proliferation of all neural elements, pathognomonic of neurofibromatosis type 1 (NF1). It involves single or multiple nerve fascicles that arises from major nerve branches(1,2). Plexiform neurofibromas are among the most common and debilitating complications of neurofibromatosis type 1 (NF1)(3). They account for substantial morbidity, including disfigurement, functional      impairment, and may even be life threatening. (4)


Full Text:



E. Rallis and D. Ragiadakou, “Giant plexiform neurofibroma in a patient with neurofibromatosis type I,” Dermatology Online Journal, vol. 15, no. 5, p. 7, 2009.

E. Savva, M. I. Vargas, J. Y. Beaulieu et al., “Giant plexiform neurofibroma in neurofibromatosis type 1,” Archives of Neurology, vol. 67, no. 3, pp. 356–357, 2010. View . at Publisher · View at Google Scholar

H. B. Skinner, Current Diagnosis and Treatment in Orthopedics, McGraw-Hill, New York, NY, USA, 3rd edition, 2003.

V. M. Riccardi, “Neurofibromatosis: clinical heterogeneity,” Current Problems in Cancer, vol. 7, no. 2, pp. 1–34, 198

R. E. Ferner and D. H. Gutmann, “International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis,” Cancer Research, vol. 62, no. 5, pp. 1573–1577, 2002.

D. A. Stumph, “Neurofibromatosis. Conference state- ment, National Institutes of Health Consensus Development Conference,” Archives of Neurology, vol. 4, no. 5, pp. 575–578, 1987.

B. R. Korf, “Malignancy in neurofibromatosis type 1,” Oncologist, vol. 5, no. 6, pp. 477–485, 2000. View at Scopus.

D. P. Beall and C. A. Vander Kolk, “Case report: giant dorsal neurofibroma in a young male,” Brain and Language, vol. 52, no. 12, pp. 958–960, 1997. View at Scopus

R. Salazar, E. B. Robotti, D. H. L. Chin, and J. A. I. Grossman, “Giant neurofibromatosis of the chest wall: two patient reports,” Annals of Plastic Surgery, vol. 41, no. 2, . pp. 211–214, 1998. View at Publisher · View at Google Scholar · View at Scopus

S. Margaritora, D. Galetta, A. Cesario, and P. Granone, “Giant neurofibroma of the chest wall,” European Journal of Cardio-thoracic Surgery, vol. 21, no. 2, p. 339, 2002. View at Publisher · View at Google Scholar · View at Scopus

L. Yang, T. Robertson, G. Tollesson, L. Francis, D. D. Campbell, and C. Winter, “An unusual presentation of a solitary benign giant neurofibroma: case report,” Journal of . Neurosurgery, vol. 11, no. 1, pp. 49–52, 2009. View at Publisher · View at Google Scholar · View

At Scopus

S. Bhatia, A. Khosla, R. Dhir, R. Bhatia, and A. K. Banerji, “Giant lumbosacral nerve sheath tumors,” Surgical Neurology, vol. 37, no. 2, pp. 118–122, 1992. View at . Publisher · View at Google Scholar · View at Scopus

A. Rekha and T. R. Gopalan, “Von Recklinghausen neurofibromatosis-pachydermatocele causing lower limb gigantism: a case report,” International Journal of Lower . Extremity Wounds, vol. 5, no. 1, pp. 61–63, 2006. View at Publisher · View at Google Scholar · View at Scopus

G. Sabbioni, N. Rani, and V. Devescovi, “Neurofibromatosis with unilateral lower limb gigantism,” Musculoskeletal Surgery, vol. 94, no. 1, pp. 41–44, 2010. View at . Publisher · View at Google Scholar · View at Scopus

J. Shimizu, Y. Arano, T. Murata et al., “A case of intrathoracic giant malignant peripheral nerve sheath tumor in neurofibromatosis type i (von recklinghausen's disease),” . Annals of Thoracic and Cardiovascular Surgery, vol. 14, no. 1, pp. 42–47, 2008. View at Scopus

A. L. Ross, Z. Panthaki, and A. D. Levi, “Surgical management of a giant plexiform neurofibroma of the lower extremity,” World Neurosurgery, vol. 75, no. 5-6, pp. 754– 757, 2011.

L. C. Argenta and M. J. Morykwas, “Vacuum-assisted closure: a new method for wound control and treatment: clinical experience,” Annals of Plastic Surgery, vol. 38, no. 6, pp. 563–577, 1997. View at Scopus

A. R. I. Ghani, A. R. Ariff, A. R. Romzi et al., “Giant nerve sheath tumour: report of six cases,” Clinical Neurology and Neurosurgery, vol. 107, no. 4, pp. 318–324, 2005. View at Publisher · View at Google Scholar · View at Scopus


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University