Cover Image




Synovial sarcoma rarely occurs in the head and neck region(3-5) . Literature reveals that primary tonsillar Synovial Sarcoma has previously been documented only in three patients (1-6) .It has generally been regarded as a high grade sarcoma. Recent analysis of clinical, morphological, and molecular characteristics of Synovial Sarcoma, however, identified low and high risk group of patients, resulting in  important implications for the treatment of patients diagnosed with Synovial Sarcoma. In all of these patients the tumor was histologically biphasic.


Full Text:



Molecular and clinicopathological findings in a tonsillar synovial sarcoma. A case study and review of the literature. Vogel U, Wehrmann M, Eichhorn W, Bültmann B, Stiegler M, Wagner W Head Neck Pathol. 2010 Sep; 4(3):257-60.

Synovial sarcoma of the head and neck: rare case of cervical metastasis. Ishiki H, Miyajima C, Nakao K, Asakage T, Sugasawa M, Motoi T Head Neck. 2009 Jan; 31(1):131-5.

Rangheard AS, Vanel D, Viala J, Schwaab G, Casiraghi O, Sigal R. Synovial sarcoma of the head and neck: CT and MR imaging findings of eight patients. Am J

Neuroradiol. 2001;22:851–857.

Engelhardt SJ, Leafstedt SW. Synovial sarcoma of tonsil and tongue base. South Med J. 1983;76 :243–244. doi: 10.1097/00007611-198302000-00025.

Shmookler BM, Enzinger FM, Brannon RB. Orofacial synovial sarcoma. Cancer. 1982;50 :269–276. doi: 10.1002/1097-0142(19820715)50:2<269::AID-CNCR2820500217>3.0.CO;2-7.

Khademi B, Bahranifard H, Mohammadianpanah M, Ashraf MJ, Azarpira N, Dehghani M. Synovial sarcoma of the palatine tonsil: report of two cases and review of the literature. Middle East J Cancer. 2010;1:141–146.

Meer S, Coleman H, Altini M. Oral synovial sarcoma: a report of 2 cases and a review of the literature.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:306–315. doi: 10.1016/S1079- 2104(03)00209-9.

Villarroel-Salinas J, Campos-Martínez J, Ortiz-Hidalgo C. Synovial sarcoma of the tongue confirmed by molecular detection of the SYT-SSX2 fusion gene transcript. Int J Surg Pathol. 2012;20 :386–389. doi: 10.1177/1066896911424897.

Weiss SW Goldblum JR Enzinger, Weiss Soft Tissue Tumors, Mosby, Louis St 2001:1483–1509. 10. Sultan I, Rodríguez-Galindo C, Saab R, et al. Comparing children adults with synovial sarcoma in the surveillance, epidemiology, and end results program, 1983–2005: an analysis of 1,268 patients. Cancer.2009; 115:3537–3547. doi: 10.1002/cncr.24424.

Raney RB. Synovial sarcoma in young people: background, prognostic factors, and therapeutic questions. J Pediatr Hematol Oncol. 2005;27:207–211. doi: 10.1097/01.mph.0000161764.60798.60.

Fisher C. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol. 1986;17:996–1002. doi: 10.1016/S0046-8177(86)80083-1.

Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401–421. doi: 10.1016/S1092- 9134(98)80042-7.

Coindre J-M, Pelmus M, Hostein I, Lussan C, Bui BH, Guillou L. Should molecular testing be required for diagnosing synovial sarcoma? Cancer. 2003;98:2700–2707. doi: 10.1002/cncr.11840.

Frisman DM. Synovial Sarcoma. (Immunoquery/Immunohistochemistry Literature Database)


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University