Cover Image




ABSTRACT INTRODUCTION Adenoid cystic    carcinoma is a rare malignant tumor of nasal cavity  constituting about 3-4 percent of all sinonasal malignancies. These tumors present with nasal obstruction and epistaxis. They have an indolent course but have high tendency for local recurrence along with perineural and haematogenous spread. Histologically they present with tubular, cribriform and solid patterns, of which solid form is associated with much aggressiveness. Lung metastasis is more common with these tumors. Local recurrence is common in adenoid cystic    carcinomas of nasal cavity. CASE REPORT A 28 year old female presented with nasal obstruction , headache for the past one year with occasional nasal bleed . Anterior   rhinoscopy revealed a fleshy, reddish , lobular mass    occupying right nasal cavity till the anterior end of inferior turbinate. Computed Tomography of Paranasal sinuses was done, which showed homogenous soft tissue mass in the inferior turbinate of right nasal cavity. Clinical diagnosis of benign tumor of the nasal cavity, Papilloma, was made .  Endoscopic assisted removal was done and suprisingly histopathologically Adenoid cystic carcinoma with cribriform pattern was reported. MRI was done to rule out perineural spread. Medial maxillectomy was done through lateral    rhinotomy approach followed by post operative   radiotherapy. CONCLUSION Adenoid cystic carcinoma  constitute 4 percent of all sinonasal malignancies This case is presented for its rarity. This is the first reported case in our institution in the past 10 years based on a recent   clinicopathological study conducted on Head and Neck Malignancies.


Full Text:



Stell PM: Adenoid cystic carcinoma. Clin Otolaryngol 1986, 11:267-291.

Spies JW: Adenoid cystic carcinoma. Arch Surg 1930, 21:365-404.

Tauxe WN, McDonald JR, Devine KD: A century of cylindromas. Arch Otolaryngol 1962, 75:1-6.

Foote FW, Frazell EL: Tumours of the major salivary glands. Cancer 1953, 6:1065-1133.

Conley J, Dingman DL: Adenoid cystic carcinoma in the head and neck (cylindroma). Arch Otolaryngol 1974, 100:81-90.

Jones AS, Hamilton JW, Rowley H, et al.: Adenoid cystic carcinoma of the head and neck.Clin Otolaryngol 1997, 22:434-443.

Stell PM, Cruikshank AH, Stoney PJ, et al.: Adenoid cystic carcinoma: the results of radical surgery. Clin Otolaryngol 1985, 10:205-208.

Spiro RH: Management of malignant tumours of the salivary glands. Oncology 1998, 12:671-680.

Matsuba HM, Spector GJ, Thawley SE, et al.: Adenoid cystic salivary gland carcinoma: ahistologic review of treatment failure patterns. Cancer 1986, 57:519-524.

Westra WH: The surgical pathology of salivary gland neoplasms. Otolaryngol Clin North Am1999, 39:919-943.

Spiro RH, Huvos AG: Stage means more than grade in adenoid cystic carcinoma. Am J Surg 1992, 164:623- 628.

Howard DJ, Lund VJ: Reflections on the management of adenoid cystic carcinoma of the nasal cavity and paranasal sinuses. Otolaryngol Head Neck Surg 1985, 93:338-341.

Prokopakis EP, Snyderman CH, Hanna EY, et al.: Risk factors for local recurrence of adenoid cystic carcinoma: the role of postoperative radiation therapy. Am J Otolaryngol 1999, 20:281-86.

Szanto PA, Luna MA, Tortoledo ME, et al: Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 1984, 54:1062-1069.

Matsuba HM, Simpson JR, Mauney M, et al.: Adenoid cystic salivary gland carcinoma: a clinico-pathologic correlation. Head Neck Surg 1986, 8:200-204.

Nagel H, Hotze HJ, Laskawi R, et al.: Cytologic diagnosis of adenoid cystic carcinoma of salivary glands. Diagn Cytopathol 1999, 20:358-366.

Preisegger K-H, Beham A, Kopp S, et al.: Prognostic impact of molecular analysis in adenoid cystic carcinomas of the salivary gland. Onkologie 2001, 24:273-277.

Doerr TD, Marentette LJ, Flint A, et al.: Urokinase-type plasminogen activator receptor expression in adenoid cystic carcinoma of the skull base. Arch Otolaryngol Head Neck Surg 2003, 129:215-218.

Cho K-J, Lee S-S, Lee Y-S: Proliferating cell nuclear antigen and

C-ERBB-2 oncoprotein expression in adenoid cystic carcinomas of the salivary glands. Head Neck 1999, 21:414-419.

Edwards PC, Bhuiya T, Kelsch RD: C-kit expression in the salivary gland neoplasms:adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenoma. Oral Surg Oral Med Oral Path Oral Radiol Endod 2003, 95:586-593.

Shirai A, Furukawa M, Yoshizaki T: Expression of intercellular adhesion molecule (ICAM)-1 in adenoid cystic carcinoma of the head and neck. Laryngoscope 2003, 1134:1955-1960.

Castler JD, Conley JJ: Surgical management of adenoid cystic carcinoma in the parotid gland.Otolaryngol

Head Neck Surg 1992, 106:332-338.

Bradley PJ: Submandibular gland and the minor salivary gland neoplasms. Otolaryngol Head Neck Surg 1999, 7:72-78.

Gormley WB, Shkhar LN, Wright DC, et al.: Management and long-term outcome of adenoid cystic carcinoma with intracranial extension: a neurosurgical perspective. Neurosurgery 1996, 38:1105-1113.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University