Liposarcoma Breast - A Case Report

Abstract

Introduction: Primary sarcomas of the breast are very rare tumours and account for less than 1% of all breast malignancies. Liposarcomas of breast has less than 0.3% of all mammary sarcomas.    Case report: We report a case of an 53yr old postmenopausal woman who presented with an asymptomatic right breast mass, of six months duration. There was no family history of breast malignancy in any     first-degree relatives and no history of previous radiation  exposure. It was clinically diagnosed as carcinoma right breast. Core needle biopsy showed poorly differentiated malignant tumour and immunohistochemistry was   positive for vimentin, S-100, Ki 67. Pre-operative diagnosis of high grade sarcoma probably liposarcoma was arrived.         Management: Simple mastectomy was done and histology showed malignant phylloides with liposarcomatous changes. Post-operative period was uneventful. Adjuvant                chemotherapy was given and the patient was discharged. Regular follow up was advised. Conclusion: The radiological, clinicopathological features, immunohistochemistry,  molecular  genetics are described in detail. Data from        similar literatures are compared and therapy recommendations discussed.