A CASE OF CAECAL GIST- RARE COEXISTENCE WITH ABDOMINAL TUBERCULOSIS

Abstract

Gastrointestinal stromal tumours (GIST) are the most
common mesenchymal tumours of the gastro intestinal tract.
The frequency of their location on the caecum is quoted with
values lower than 10 of all GIST. Nearly 95 of GIST are
positive for the CD 117 antigen, an epitope of KIT receptor
tyrosine kinase expressed by their cell of origin, the Interstitial
Cells of Cajal (ICC). Immunohistochemistry for CD117 is
completely negative in approximately 5 of GISTs, though the
morphological, molecular and the cytogenetic features are the
same. Tuberculosis can involve any part of the
gastrointestinal tract and is the sixth most frequent site of
extra pulmonary involvement. The most common site of
involvement of the gastrointestinal tuberculosis is the
ileocaecal region which can present as a palpable mass in the
right lower quadrant andor complication of obstruction.
Keyword :Tuberculosis, Gastrointestinal stromal tumour,
CD117, KIT receptor, Imatinib.